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Past Projects by Therapy

Selected Papers by Integrative Therapy

Throughout our 25-year history, we have conducted rigorous research on many different integrative therapies, including:

Click on the topics below to read more details:


  1. Zhang R, Lao L, Ren K, Berman BM.  Mechanisms of Acupuncture-Electroacupuncture on Persistent Pain.  Anesthesiology. 2013 Dec 9. [Epub ahead of print]  PMID: 24322588. PMCID: PMC3947586.

  2. Manheimer E, Wieland LS, Cheng K, Min Li SM, Shen X, Berman BM, Lao L.  Acupuncture for Irritable Bowel Syndrome:  Systematic Review and Meta-Analysis.  The American Journal of Gastroenterology.  10 April 2012 [Epub ahead of print].  doi: 10.1038/ajg.2012.66. PMID: 22592702. PMCID: PMC3718572

  3. Berman BM, Langevin HM, Witt CM, Dubner R.  Acupuncture for Chronic Low Back Pain.  N Engl J Med. 2010 Jul 29;363(5):454-461.  PMID: 20818865

  4. Manheimer E, Cheng K, Linde K, Lao L, Yoo J, Wieland S, van der Windt DAWM, Berman BM, Bouter LM. Acupuncture for peripheral joint osteoarthritis. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD001977. DOI: 10.1002/14651858.CD001977.pub2. PMID: 20091527. PMCID: PMC3169099

  5. Ee C, Manheimer E, Pirotta M, White A.  Acupuncture for pelvic and back pain in pregnancy: a systematic review.  American Journal of Obstetrics & Gynecology.  2008 March;198(3):254-9. PMID: 18313444

  6. Kundu A, Berman B.  Acupuncture for Pediatric Pain and Symptom Management.  Pediatr Clin N Am.  2007;54: 885–899. 

  7. Li A, Wang Y, Xin J, Lao L, Ren K, Berman B, Zhang R-X.  Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system.  Brain Research.  2007 Dec 19;1186:171-9. PMCID: PMC2200297

  8. Berman B. A 60-Year-Old Woman Considering Acupuncture for Knee Pain.  JAMA; Clinical Crossroads. 2007; 297(15):1697-1707.

  9. Langevin H, Hammerschlag R, Lao L, Napadow V, Schnyer R, Sherman K.  Controversies in Acupuncture Research:  Selection of Controls and Outcome Measures in Acupuncture Clinical Trials.  The Journal of Alternative and Complementary Medicine. 2006;12(10):943-953.

  10. Manheimer E, Lim B, Lao L, Berman B.  Acupuncture for knee osteoarthritis – a randomized trial using a novel sham.  Acupuncture in Medicine. 2006 Dec;24 Suppl:S7-14.

  11. Berman B, Lao L, Langenberg P, Lee WL, Gilpin A, Hochberg M. Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial. Annals of Internal Medicine. 2004; 141(12):901-910.

  12. Lao L, Hamilton G, Fu J, Berman B. Is acupuncture safe? A systematic review of case reports. Alternative Therapies. 2003;9(1):72-83.

  13. Singh BB, Berman B, Hadhazy V, Bareta J, Lao L, Zarow FM, Hochberg MC. Clinical decisions in the use of  acupuncture as an adjunctive therapy for osteoarthritis of the knee. Alternative Therapies. 2001;7(4): 58-65.

  14. Ezzo J, Hadhazy V, Birch S, Lao L, Kaplan G, Hochberg M, Berman B. Acupuncture for Osteoarthritis  of the Knee: A systematic review. Arthritis Rheumatism. 2001;44(4):819-825.

  15. Berman B, Swyers JP, Ezzo J. The evidence for acupuncture as a treatment for rheumatologic conditions. Rheumatic Diseases Clinics of North America. 2000; 26(1):103-115, ix-x. Review.


  1. Tarantino B, Earley M, Audia D, D'Adamo C, Berman B.  Qualitative and quantitative evaluation of a pilot integrative coping and resiliency program for healthcare professionals.  Explore (NY). 2013 Jan;9(1):44-7. doi: 10.1016/j.explore.2012.10.002.  PMID: 23294820


D'Adamo CR, McMillin CR, Chen KW, Lucas EK, Berman BM.  Supervised Resistance Exercise for Patients with Persistent Symptoms of Lyme Disease.  Med Sci Sports Exerc. 2015 Apr 18. [Epub ahead of print]  PMID: 25899100

Resnick B, D'Adamo C.  Factors associated with exercise among older adults in a continuing care retirement community.  Rehabil Nurs. 2011 Mar-Apr;36(2):47-53, 82.  PMID: 21473560


  1. Greeson JM, Toohey MJ, Pearce MJ.  An Adapted, Four-Week Mind-Body Skills Group for Medical Students: Reducing Stress, Increasing Mindfulness, and Enhancing Self-Care.  Explore (NY). 2015 Feb 16. pii: S1550-8307(15)00029-4. doi: 10.1016/j.explore.2015.02.003. [Epub ahead of print]  PMID: 25792145

  2. Earley MD, Chesney MA, Frye J, Greene PA, Berman B, Kimbrough E.  Mindfulness Intervention for Child Abuse Survivors: A 2.5-Year Follow-Up.  J Clin Psychol. 2014 May 20. doi: 10.1002/jclp.22102. [Epub ahead of print]  PMID:  24844944

  3. Chen KW, Berger CC, Manheimer E, Forde D, Magidson J, Dachman L, Lejuez CW.  Meditative therapies for reducing anxiety: a systematic review and meta-analysis of randomized controlled trials.  Depress Anxiety. 2012 Jul; 29(7):545-62. doi: 10.1002/da.21964. Epub 2012 Jun 14. Review.  PMID: 22700446. PMCID: PMC3718554

  4. Pradhan EK, Baumgarten M, Langenberg P, Handwerger B, Gilpin AK, Magyari T, Hochberg M, Berman B.  The Effect of Mindfulness-Based Stress Reduction in Rheumatoid Arthritis Patients.  Arthritis & Rheumatism. 2007;57(7):1134-1142.

  5. Astin J.  Mind-Body Therapies for the Management of Pain.  Clinical Journal of Pain. 2004; 20(1):27-32.

  6. Pelletier KR. Mind-Body medicine in ambulatory care: An evidence based assessment. Journal of Ambulatory Care Management 2004; 27(1): 25-42.

  7. Astin JA, Shapiro LS, Eisenberg DM, Forys KL. Mind-body medicine: State of the science, implications for practice. Journal of the American Board of Family Practice 2003;16(2):131-147.


  1. D'Adamo C, McArdle P, Balick L, Peisach E, Ferguson T, Diehl A, Bustad K, Bowden B, Pierce B, Berman B.  Spice MyPlate: Nutrition Education Focusing Upon Spices and Herbs Improved Diet Quality and Attitudes Among Urban High School Students.  Am J Health Promot. 2015 Jul 9. [Epub ahead of print]  PMID:  PMID: 26158684

  2. Ranke TD, Mitchell CL, St George DM, D'Adamo CR.  Evaluation of the Balanced Menus Challenge: a healthy food and sustainability programme in hospitals in Maryland.  Public Health Nutr. 2014 Dec 29:1-9. [Epub ahead of print]  PMID: 25543666

  3. Santesso N, Manheimer E.  A Summary of a Cochrane Review: Green and Black Tea for the Primary Prevention of Cardiovascular Disease.  Glob Adv Health Med. 2014 Mar;3(2):66-67. Review.  PMID:  24808983. PMCID: PMC4010958

  4. D’Adamo CR, Sahin A. Soy Foods and Supplementation: A Review of Common Perceived Health Benefits and Risks. Alternative Therapies in Health and Medicine. 2014 Jan;20 Supp 1:39-51.  PMID:  24473985

  5. Mathie RT, Frye J, Fisher P.  Homeopathic Oscillococcinum(®) for preventing and treating influenza and influenza-like illness.  Cochrane Database Syst Rev. 2012 Dec 12;12:CD001957. doi: 10.1002/14651858.CD001957.pub5.  PMID: 23235586

  6. D'Adamo CR, Miller RR, Shardell MD, Orwig DL, Hochberg MC, Ferrucci L, Semba RD, Yu-Yahiro JA, Magaziner J, Hicks GE.  Higher serum concentrations of dietary antioxidants are associated with lower levels of inflammatory biomarkers during the year after hip fracture.  Clin Nutr. 2012 Oct;31(5):659-65. doi: 10.1016/j.clnu.2012.01.013. Epub 2012 Feb 25.  PMID: 22365613. PMCID: PMC3412071

  7. Shardell M, D'Adamo C, Alley DE, Miller RR, Hicks GE, Milaneschi Y, Semba RD, Cherubini A, Bandinelli S, Ferrucci L.  Serum 25-Hydroxyvitamin D, Transitions Between Frailty States, and Mortality in Older Adults: The Invecchiare in Chianti Study.  J Am Geriatr Soc. 2012 Jan 27. doi: 10.1111/j.1532-5415.2011.03830.x. [Epub ahead of print]  PMID: 22283177. PMCID: PMC3288698

  8. D'Adamo CR, Miller RR, Hicks GE, Orwig DL, Hochberg MC, Semba RD, Yu-Yahiro JA, Ferrucci L, Magaziner J, Shardell MD.  Serum Vitamin E Concentrations and Recovery of Physical Function During the Year After Hip Fracture. J Gerontol A Biol Sci Med Sci. 2011 Apr. [Epub ahead of print] PMID: 21486921 [PubMed - as supplied by publisher] PMCID: PMC3143347

  9. D'Adamo CR, Shardell MD, Hicks GE, Orwig DL, Hochberg MC, Semba RD, Yu-Yahiro JA, Ferrucci L, Magaziner JS, Miller RR.  Serum vitamin E concentrations among highly functioning hip fracture patients are higher than in nonfracture controls.  Nutr Res. 2011 Mar;31(3):205-14.  PMID: 21481714 [PubMed - in process]

  10. Yu YB, Dosanjh L, Lao L, Tan M, Shim BS, Luo Y. Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways. PLoS One 2010;5(2):e9339.  PMID: 20179756. PMCID: PMC2825258

  11. Kim HR, Rajaiah R, Wu Q, Satpute S, Tan M, Simon J, Berman B, Moudgil K. Green Tea Protects Rats against Autoimmune Arthritis by Modulating Disease-Related Immune Events.  The Journal of Nutrition. 2008 Nov;138(11):2111-6.  PMID: 18936206. PMCID: PMC2693422

  12. Cao H, Yu R, Choi Y, Ma ZZ, Zhang H, Xiang W, Lee D, Berman B, Moudgil K, Fong H, van Breemen R.  Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.  Pharmacological Research.  2010 Jun;61(6):519-24. Epub 2010 Feb 24.  PMID: 20188172. PMCID: PMC2860736


  1. Chen KW, Hou F, Litchbroun AS. Two Cases of Complete Recovery from Fibromyalgia Syndrome after External Qigong Therapy.  Alternative & Integrative Medicine. 21 Sept 2014; 3:4.

  2. Chen KW, Comeford A, Shinnick P, Ziedonis DM.  Introducing Qigong meditation into residential addiction treatment:  a pilot study where gender makes a difference.  J Altern Complement Med. 2010 Aug 17, 16(8):875-882.  PMID: 20649456

  3. Shao LX, Zhang JP, Chen L, Zhang XF, Chen KW. Effects of external qi or qigong with opposing intentions on proliferation of E-coli. The Journal of Alternative and Complementary Medicine. 2009;15(5): 567-571.  PMID: 19425820

  4. Chen KW, Liu TJ. Zhang HB, Ling ZP.  An analytical review of the Chinese literature on Qigong therapy for diabetes mellitus.  American Journal of Chinese Medicine. 2009; 37(3): 439-457.  PMID: 19606506

  5. Lee MS, Chen KW, Choi TY, Ernst E. Qigong for type 2 diabetes care: a systematic review. Complementary Therapies in Medicine, 2009 Aug;17(4):236-42.  PMID: 19632552


  1. Koenig HG, Pearce MJ, Nelson B, Daher N.  Effects of Religious Versus Standard Cognitive-Behavioral Therapy on Optimism in Persons with Major Depression and Chronic Medical Illness. Depress Anxiety. 2015 Jul 28. doi: 10.1002/da.22398. [Epub ahead of print]  PMID: 26219426

  2. Pearce MJ, Medoff D, Lawrence RE, Dixon L.  Religious Coping Among Adults Caring for Family Members with Serious Mental Illness.  Community Ment Health J. 2015 Apr 21. [Epub ahead of print]  PMID: 25895855

  3. Koenig HG, Pearce MJ, Nelson B, Shaw SF, Robins CJ, Daher NS, Cohen HJ, Berk LS, Bellinger DL, Pargament KI, Rosmarin DH, Vasegh S, Kristeller J, Juthani N, Nies D, King MB.  Religious vs. Conventional Cognitive Behavioral Therapy for Major Depression in Persons With Chronic Medical Illness: A Pilot Randomized Trial.  J Nerv Ment Dis. 2015 Apr;203(4):243-51. doi: 10.1097/NMD.0000000000000273.  PMID: 25816046

  4. Pearce MJ, Koenig HG, Robins CJ, Nelson B, Shaw SF, Cohen HJ, King MB.  Religiously integrated cognitive behavioral therapy: a new method of treatment for major depression in patients with chronic medical illness.  Psychotherapy (Chic). 2015 Mar;52(1):56-66. doi: 10.1037/a0036448. Epub 2014 Nov 3.  PMID: 25365155

  5. Koenig HG, Berk LS, Daher NS, Pearce MJ, Bellinger DL, Robins CJ, Nelson B, Shaw SF, Cohen HJ, King MB.  Religious involvement is associated with greater purpose, optimism, generosity and gratitude in persons with major depression and chronic medical illness. J Psychosom Res. 2014 Aug;77(2):135-43. doi: 10.1016/j.jpsychores.2014.05.002. Epub 2014 May 15.   PMID: 25077855

  6. Pearce MJ, Koenig HG, Robins C, Nelson B, Shaw S, Cohen H, & King M. Religiously-integrated cognitive behavioral therapy: A new method of treatment for major depression in patients with chronic medical illness. Psychotherapy: Theory, Research, and Practice. 2014; Advance online publication.

  7. Kim HJ, Pearce MJ, Choi-Kwon S. Religious attendance, health-promoting behavior, and depressive symptoms among Koreans in the United Arab Emirates. Journal of Immigrant and Minority Health. 2014; Online first DOI 10.1007/s10903-014-0057-0.

  8. Pearce MJ & Koenig HK. Cognitive behavioral therapy for the treatment of depression in Christian patients with medical illness. Mental Health, Religion, and Culture. (2012). Online first (

  9. Pearce MJ, Coan A, Herndon JE, Koenig HG, & Abernethy A. Unmet spiritual care needs impact emotional and spiritual well-being in advanced cancer patients. Supportive Care in Cancer. (2012). Online first10.1007/s00520-011-1335-1. PMID: 22124529


  1. Lao L, Hochberg M, Lee DY, Gilpin AM, Fong HH, Langenberg P, Chen K, Li EK, Tam LS, Berman B.  Huo-Luo-Xiao-Ling (HLXL)-Dan, a Traditional Chinese Medicine, for Patients with Osteoarthritis of the Knee: A Multi-site, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial.  Osteoarthritis Cartilage. 2015 Jun 19. pii: S1063-4584(15)01215-7. doi: 10.1016/j.joca.2015.06.007. [Epub ahead of print]  PMID: 26099553

  2. Moudgil KD, Berman BM.  Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis.  Expert Rev Clin Immunol. 2014 May 12:1-4. [Epub ahead of print] 

  3. Yang Z, Grinchuk V, Ip SP,  Che CT, Fong HHS, Lao L, Wu J, Sung JJ, Berman B, Shea-Donohue T, Zhao A.  Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. Vol. 2012, Article ID 491496, 12 pages, 2012. doi:10.1155/2012/491496. PMID: 22461841. PMCID: PMC3296463

  4. Yang YH, Rajaiah R, Lee DY, Ma Z, Yu H, Fong HH, Lao L, Berman BM, Moudgil KD. Suppression of ongoing experimental arthritis by a Chinese herbal formula (huo-luo-xiao-ling dan) involves changes in antigen-induced immunological and biochemical mediators of inflammation. Evid Based Complement Alternat Med. 2011;2011:642027. Epub 2010 Oct 19.  PMID: 20981317 [PubMed - in process] PMCID: PMC2958519

  5. Zhang RX, Fan AY, Zhou AN, Moudgil KD, Ma ZZ, Lee DY, Fong HH, Berman BM, Lao L.  Extract of the Chinese herbal formula Huo Luo Xiao Ling Dan inhibited adjuvant arthritis in rats.  J Ethnopharmacol. 2009 Jan 30;121(3):366-71. Epub 2008 Nov 28.  PMID: 19100323. PMCID: PMC2818782

  6. Manheimer E, Wieland S, Kimbrough E, Cheng K, Berman B.  Evidence from the Cochrane Collaboration for traditional Chinese medicine therapies.  J Altern Complement Med. 2009 Sep;15(9):1001-14. PMID: 19757977.  PMCID: PMC2856612